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Isoflupredone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isoflupredone图片
规格:98%
分子量:378.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
异氟泼酮属于皮质类固醇类,通过与动物(如马)的糖皮质激素和盐皮质激素受体结合发挥作用。
货号:ajcx26204
CAS:338-95-4
分子式:C21H27FO5
分子量:378.4
溶解度:DMSO: Slightly,Ethyl Acetate: Slightly
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Isoflupredone is an agonist of glucocorticoid and mineralocorticoid receptors (EC50s = 0.877 and 0.007 nM, respectively, in transactivation assays).1It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50= 25.5 nM).2Topical application of a solution containing isoflupredone inhibits croton oil-induced ear edema in rats (ED50= 51.9 nM). Isoflupredone (0.6 mg/day) increases mean arterial pressure (MAP) and decreases the levels of potassium and sodium in the plasma and urine, respectively, in sheep.3It reduces tumor levels of uridine incorporation into 18S and 28S rRNA in a P1798 murine lymphoma model when administered at a dose of 25 mg/kg.4


1.Grossmann, C., Scholz, T., Rochel, M., et al.Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: A comparison of their glucocorticoid and mineralocorticoid propertiesEur. J. Endocrinol.151(3)397-406(2004) 2.Park, K.-K., Ko, D.-H., You, Z., et al.Synthesis and pharmacological evaluations of new steroidal anti-inflammatory antedrugs: 9α-Fluoro-11β,17α,21-trihydroxy-3,20-dioxo-pregna-1,4-diene-16α-carboxylate (FP16CM) and its derivativesSteroids71(1)83-89(2006) 3.Coghlan, J.P., Denton, D.A., Mills, E.H., et al.Steroid antagonism of the ’hypertensinogenic’ activity of 9α-fluoroprednisoloneLife Sci.35(26)2609-2612(1984) 4.Stevens, J., Mashburn, L.T., and Hollander, V.P.Effect of 9α-fluoroprednisolone and ?-asparaginase on uridine incorporation into ribosomal RNA of P1798 lymphosarcomaBiochim. Biophys. Acta186(2)332-339(1969)