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Metanephrine-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metanephrine-d3(hydrochloride)图片
规格:98%
分子量:236.7
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of metanephrine
货号:ajcx25802
CAS:1215507-88-2
分子式:C10H12D3NO3·HCl
分子量:236.7
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 15 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Metanephrine-d3is intended for use as an internal standard for the quantification of metanephrine by GC- or LC-MS. Metanephrine is an inactive metabolite of epinephrine .1It is formed from epinephrine by catechol-O-methyl transferase (COMT).2Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.3,4


1.Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E.Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclaseBiochem. Pharmacol.27(10)1445-1454(1978) 2.Kopin, I.J., Axelrod, J., and Gordon, E.The metabolic fate of H3-epinephrine and C14-metanephrine in the ratJ. Biol. Chem.236(7)2109-2136(1961) 3.Wolthers, B.G., Kema, I.P., Volmer, M., et al.Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometryClin. Chem.43(1)114-120(1997) 4.Goldstein, D.S., Eisenhofer, G., and Kopin, I.J.Sources and significance of plasma levels of catechols and their metabolites in humansJ. Pharm. Exp. Ther.305(3)800-811(2003)