An agonist of TLR1/2
货号:ajcx25076
CAS:903864-87-9
分子式:C16H23N3O3S
分子量：337.4
溶解度:DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.¹It induces NF-κB signaling in cells expressing human TLR2 (EC₅₀= 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM.In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

1.Chen, Z., Cen, X., Yang, J., et al.Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library databaseChem. Commun. (Camb.)54(81)11411-11414(2018)