An internal standard for the quantification of tauro-β-muricholic acid
货号:ajcx25006
CAS:N/A
分子式:C26H40D4NO7S·Na
分子量：541.7
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tauro-β-muricholic acid-d₄(TβMCA-d₄) is intended for use as an internal standard for the quantification of TβMCA by GC- or LC-MS. TβMCA is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC₅₀= 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid .¹TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.^1,2TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.³

1.Sayin, S.I., WahlstrÖm, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013) 2.WahlstrÖm, A., Kovatcheva-Datchary, P., StÅhlman, M., et al.Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiotaJ. Lipid. Res.58(2)412-419(2017) 3.Qi, Y., Jiang, C., Cheng, J., et al.Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in miceBiochim. Biophys. Acta.1851(1)19-29(2015)