Background:

Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.¹It inhibits NADH fumarate reductase (NFRD; IC₅₀= 1.7 µM inA. suummitochondria) and NADH oxidase (IC₅₀= 3 µM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andM. smegmatisin disc assays.

1.Kaifuchi, S., Mori, M., Nonaka, K., et al.Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897J. Antibiot. (Tokyo)68(6)403-405(2015)