A neuropeptide with diverse biological activities
货号:ajcx23330
CAS:N/A
分子式:C20H23D9O5
分子量：361.5
溶解度:DMF: 100 mg/ml,DMSO: 50 mg/ml,Ethanol: 75 mg/ml,PBS (pH 7.2): 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin D₂-d₉(PGD₂-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGD₂by GC-or LC-mass spectrometry. PGD₂is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes.¹PGD₂is also produced in the brainviaan alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.^2,3In the brain, PGD₂produces normal physiological sleep and lowering of body temperature.^2,3Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴PGD₂inhibits human ovarian tumor cell proliferation with an IC₅₀value of 6.8 µM.⁵

1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H., Ueno, R., Fujita, I., et al.Prostaglandin D2, a cerebral sleep-inducing substance in monkeysProc. Natl. Acad. Sci. U.S.A.85(11)4082-4086(1988) 4.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988) 5.Kikuchi, Y., Kita, T., Hirata, J., et al.Preclinical studies of antitumor prostaglandins by using human ovarian cancer cellsCancer Metastasis Rev.13(3-4)309-315(1994)