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NUCC-390(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NUCC-390(hydrochloride)图片
规格:98%
分子量:468.5
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23156
CAS:N/A
分子式:C23H33N5O.2HCl
分子量:468.5
溶解度:DMSO: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.1It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 . NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons.2In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.3


1.Mishra, R.K., Shum, A.K., Platanias, L.C., et al.Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonistsSci. Rep.6:301551-9(2016) 2.Zanetti, G., Negro, S., Megighian, A., et al.A CXCR4 receptor agonist strongly stimulates axonal regeneration after damageAnn. Clin. Transl. Neurol.6(12)2395-2402(2019) 3.Stazi, M., D'Este, G., Mattarei, A., et al.An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomationPLoS Negl. Trop. Dis.14(9)e0008547(2020)