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JWH 200 7-hydroxyindole metabolite
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JWH 200 7-hydroxyindole metabolite图片
规格:98%
分子量:400.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22740
CAS:N/A
分子式:C25H24N2O3
分子量:400.5
溶解度:Acetonitrile: 14 mg/ml,DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.1 mg/ml,DMSO: 20 mg/ml,Methanol: 2 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor agonist, binding the CB1receptor with high-affinity (IC50= 7.8-42 nM).1,2JWH 200 is one of several synthetic CBs which have been included in smoking mixtures.3JWH 200 7-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 200 based on the metabolism of the closely related JWH 015 and JWH 018.4,5


1.Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al.Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimeticsJournal of Medicinal Chemistry383094-3105(1995) 2.Huffman, J.W., Mabon, R., Wu, M.J., et al.3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptorBioorganic & Medicinal Chemistry11539-549(2003) 3.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 4.Zhang, Q., Ma, P., Cole, R.B., et al.Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MSAnalytical and Bioanalytical Chemistry3861345-1355(2006) 5.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)