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JP-1302(hydrochloride hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JP-1302(hydrochloride hydrate)图片
规格:98%
分子量:441.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An α2C-adrenergic receptor antagonist
货号:ajcx22700
CAS:N/A
分子式:C24H24N4.2HCl [XH2O]
分子量:441.4
溶解度:DMSO: Soluble,Water: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively).1It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice.2JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.3


1.Sallinen, J., HÖglund, I., EngstrÖm, M., et al.Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302Br. J. Pharmacol.150(4)391-402(2007) 2.Imaki, J., Mae, Y., Shimizu, S., et al.Therapeutic potential of α2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disordersNeurosci. Lett.454(2)143-147(2009) 3.Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I., et al.Effect of selective blockade of α?-adrenoceptor subtypes on cardiovascular system in ratsBull. Exp. Biol. Med.158(4)410-412(2015)