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Eplerenone-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eplerenone-d3图片
包装:2.5mg
规格:98%
市场价:9261元
分子量:417.5

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22432
CAS:N/A
分子式:C24H27D3O6
分子量:417.5
溶解度:
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Eplerenone-d3is intended for use as an internal standard for the quantification of eplerenone by GC- or LC-MS. Eplerenone is a mineralocorticoid receptor antagonist.1It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC50= 122 nM).In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction.2Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.


1.Meyers, M.J., Arhancet, G.B., Hockerman, S.L., et al.Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathyJ. Med. Chem.53(16)5979-6002(2010) 2.Chen, B., Geng, J., Gao, S.-X., et al.Eplerenone modulates interleukin-33/sST2 signaling and IL-1β in left ventricular systolic dysfunction after acute myocardial infarctionJ. Interferon. Cytokine Res.38(3)137-144(2018)