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Diquat-d12(bromide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diquat-d12(bromide)图片
规格:98%
分子量:356.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22312
CAS:N/A
分子式:C12D12N2.2Br
分子量:356.1
溶解度:DMSO: 1 mg/ml,Ethanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Diquat-d12is intended for use as an internal standard for the quantification of diquat by GC- or LC-MS. Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.


1.Moreland, D.E.Mechanisms of action of herbicidesAnn. Rev. Plant Physiol.31597-638(1980) 2.Cao, S., Wu, H., Wang, C., et al.Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in pigletsJ. Anim. Sci.96(5)1795-1805(2018) 3.Singh, P., Hanson, P.S., and Morris, C.M.Sirtuin-2 protects neural cells from oxidative stress and is elevated in neurodegenerationParkinsons Dis.2017:2643587(2017) 4.TomÁšek, O., GabrielovÁ, B., Ka?er, P., et al.Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signallingSci. Rep.6:23546(2016)