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Diclofenac-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diclofenac-d4图片
规格:98%
分子量:300.2
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of diclofenac
货号:ajcx22268
CAS:153466-65-0
分子式:C14H7D4Cl2NO2
分子量:300.2
溶解度:DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml,Water: 50 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Diclofenac-d4contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.1,2,3It inhibits human COX-1 and -2 with IC50values of 0.9-2.7 and 1.5-20 µM, respectively.1,2Diclofenac inhibits ovine COX-1 and -2 with IC50values of 60 and 220 nM, respectively.3


1.Laneuville, O., Breuer, D.K., DeWitt, D.L., et al.Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugsJ. Pharmacol. Exp. Ther.271(2)927-934(1994) 2.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 3.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995)