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Apigenin-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apigenin-d5图片
规格:98%
分子量:275.3
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of apigenin
货号:ajcx21688
CAS:263711-74-6
分子式:C15H5D5O5
分子量:275.3
溶解度:DMSO: Soluble,Methanol: Sparingly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Apigenin-d5is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.1CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.2Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.3


1.Yamada, M., Katsuma, S., Adachi, T., et al.Inhibition of protein kinase CK2 prevents the progression of glomerulonephritisProceedings of the National Academy of Sciences of the United States of America102(21)7736-7741(2005) 2.Shen, J., Channavajhala, P., Seldin, D.C., et al.Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IκBα1Journal of Immunology1679)4919-4925(2001) 3.Raso, G.M., Meli, R., Di Carlo, G., et al.Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1Life Sciences68(8)921-931(2001)