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A6770
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A6770图片
规格:98%
分子量:140.1
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
A6770 是一种具有口服活性的强效 1-磷酸鞘氨醇 (S1P) 裂解酶 (S1PL) 抑制剂。
货号:ajcx21570
CAS:1331754-16-5
分子式:C6H8N2O2
分子量:140.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50=<0.01 µM), an effect that is reduced in the presence of vitamin B6(EC50=<100 µM).


1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)