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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline图片
规格:98%
分子量:219.1
包装与价格：
包装价格(元)
1g电议
5g电议
10g电议

产品介绍
A heterocyclic building block
货号:ajcx21362
CAS:214360-73-3
分子式:C12H18BNO2
分子量：219.1
溶解度:DMF: 20mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 10mg/mL,Ethanol: 3mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline is a heterocyclic building block.1,2It has been used in the synthesis of 3-aminoindazole-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity and roscovitine derivatives that are dual inhibitors of cyclin-dependent kinases (CDKs) and casein kinase 1 (CK1).


1.Dai, Y., Hartandi, K., Ji, Z., et al.Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitorJ. Med. Chem.50(7)1584-1597(2007) 2.Paraiso, K.H.T., Haarberg, H.E., Wood, E., et al.The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsClin. Cancer Res.18(9)2502-2514(2012)