A neuropeptide with diverse biological activities
货号:ajcx21074
CAS:N/A
分子式:C20H25D9O5
分子量：363.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

11β-Prostaglandin F_2α-d₉(11β-PGF_2α-d₉) is intended for use as an internal standard for the quantification of 11β-PGF_2αby GC- or LC-MS. 11β-PGF_2αis the primary metabolite of PGD₂.¹It is formed from PGD₂viathe NADPH-dependent aldo-keto reductase PGF synthase in the liver or lung.²11β-PGF_2αinduces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF_2α(FP) receptors, with an EC₅₀value of 0.045 µM.¹It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.³11β-PGF_2α(0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.⁴

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