TGFβRI-IN-3 抑制 TGFβR1 的 IC50 为 0.79 nM，选择性是 MAP4K4 的 2000 倍。TGFβRI-IN-3 是一种高选择性 TGFβR1 抑制剂，在免疫肿瘤中有潜在的应用价值。
货号:ajcx36274
CAS:N/A
分子式:C28H23N3O2S
分子量：465.57
溶解度:DMSO : 50 mg/mL (107.40 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology[1].

TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4[1].

[1]. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.