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TGFβRI-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TGFβRI-IN-3图片
规格:98%
分子量:465.57
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
TGFβRI-IN-3 抑制 TGFβR1 的 IC50 为 0.79 nM,选择性是 MAP4K4 的 2000 倍。TGFβRI-IN-3 是一种高选择性 TGFβR1 抑制剂,在免疫肿瘤中有潜在的应用价值。
货号:ajcx36274
CAS:N/A
分子式:C28H23N3O2S
分子量:465.57
溶解度:DMSO : 50 mg/mL (107.40 mM; ultrasonic and warming and heat to 60°C)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology[1].

TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4[1].

[1]. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.