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Amino-PEG2-C2-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amino-PEG2-C2-acid图片
规格:98%
分子量:177.2
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Amino-PEG2-C2-acid 是一种可降解 (cleavable) 的 3 单元 PEG 类的 ADC linker,用于抗体偶联药物 (ADC) 的合成。Amino-PEG2-C2-acid 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
货号:ajcx36110
CAS:791028-27-8
分子式:C7H15NO4
分子量:177.2
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof. WO2016197946A1.