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Bromo-PEG2-C2-azide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bromo-PEG2-C2-azide图片
规格:98%
分子量:238.08
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Bromo-PEG2-C2-azide 是一种不可降解的 ADC linker,用于合成抗体偶联药物 (ADC)。Bromo-PEG2-C2-azide 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
货号:ajcx36014
CAS:530151-56-5
分子式:C6H12BrN3O2
分子量:238.08
溶解度:DMSO : 100 mg/mL (420.03 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.