CDK4-IN-1-d6 是一种 CDK4-IN-1 氘代物。CDK4-IN-1 (compound 63) 是一种 CDK4 抑制剂 (IC50= 10 nM)。
货号:ajcx34618
CAS:N/A
分子式:C22H23D6ClN8
分子量：447.01
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK4-IN-1-d6 is a deuterium labeled CDK4-IN-1. CDK4-IN-1 (compound 63) is a CDK4 inhibitor (IC50= 10 nM)[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[1].

[1]. Cho YS, Borland M, Brain C, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem. 2010;53(22):7938-7957.
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.