[D-p-Cl-Phe6,Leu17]-VIPTFA是一种竞争性和选择性的血管活性肠肽(VIP)受体拮抗剂，IC50值为125.8nM。[D-p-Cl-Phe6,Leu17]-VIPTFA对胰高血糖素，促胰液素和GRF受体无活性。
货号:ajcx32426
CAS:N/A
分子式:C150H240F3ClN44O44
分子量：3456.22
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors[1][2][3].

[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.