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Soyasaponin II
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Soyasaponin II图片
包装:1mg
规格:98%
市场价:1336元
分子量:913.1

产品介绍
SoyasaponinII是具有抗病毒活性的皂苷。SoyasaponinII抑制HSV-1,HCMV,流感病毒和HIV-1的复制。SoyasaponinII对HSV-1复制显示出有效的抑制作用。SoyasaponinII作为YB-1磷酸化和NLRP3炎性小体引发的抑制剂,可保护小鼠免受LPS/GalN诱导的急性肝衰竭。
货号:ajcx31484
CAS:55319-36-3
分子式:C47H76O17
分子量:913.1
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].

[1]. Hayashi K, et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 1997;63(2):102-105. [2]. Wang F, et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics. 2020;10(6):2714-2726. Published 2020 Feb 3.