Phenidone是一种具有口服活性的，环氧化酶(COX)和脂氧合酶(LOX)的双重抑制剂，可以改善实验性自身免疫性脑脊髓炎大鼠的瘫痪。Phenidone是一种对自发性高血压大鼠有效的降压剂。Phenidone用作照片显像剂。
货号:ajcx31290
CAS:92-43-3
分子式:C9H10N2O
分子量：162.19
溶解度:DMSO: 100 mg/mL (616.56 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].

Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].

Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].

[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.