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PKRA 7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PKRA 7图片
包装:5mg
规格:98%
市场价:2255元
分子量:541.48

产品介绍
C27H34ClFN2O4.HCl
货号:ajcx28108
CAS:N/A
分子式:C27H34ClFN2O4.HCl
分子量:541.48
溶解度:DMSO|54.15|100|
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo. Brain penetrant. Cell-permeable.