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AZ 1729
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ 1729图片
包装:10mg
规格:98%
市场价:3298元
分子量:369.42

产品介绍
AZ 1729 是一种有效的游离脂肪酸 2 受体 (FFA2) 激活剂,可作为直接变构激动剂和正变构调节剂。
货号:ajcx27830
CAS:2016864-46-1
分子式:C18H16FN5OS
分子量:369.42
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.


Bolognini et al (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. J.Biol.Chem. 291 18915 PMID:27385588 |Sergeev et al (2017) A single extracellular amino acid in free fatty acid receptor 2 defines antagonist species selectivity and G protein selection bias. Sci.Rep. 7 13741 PMID:29061999