NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂,IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。
货号:ajcx27660
CAS:N/A
分子式:C161H275N55O29
分子量:3445.26
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:
现货Background:
Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.
Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID:28757184