Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs
货号:ajcx27354
CAS:1435934-00-1
分子式:C25H22N6.2HCl
分子量：479.4
溶解度:DMF: 1 mg/ml,DMSO: 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).

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