JZP 361 是一种有效、可逆和选择性的人重组 MAGL (hMAGL) 抑制剂，IC50 为 46 nM。
货号:ajcx27274
CAS:1680193-80-9
分子式:C22H20ClN5O
分子量：405.88
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Patel et al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436 PMID:25752982