Tariquidar dihydrochloride (XR9576 dihydrochloride) 是一种有效且特异性的 P-糖蛋白 (P-gp) 抑制剂，具有高亲和力 (Kd=5.1 nM)。
货号:ajcx27218
CAS:1992047-62-7
分子式:C38H38N4O6.2HCl
分子量：719.66
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin and mitoxantrone in vitro.

Kannan et al (2011) The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2 82 PMID:22778859 |Loo et al (2015) Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 290 29389 PMID:26507655