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Guangxitoxin 1E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guangxitoxin 1E图片
包装:100ug
规格:98%
市场价:4206元
分子量:3948.61

产品介绍
Guanxitoxin 1E 是 KV2.1 和 KV2.2 通道的有效选择性阻断剂。
货号:ajcx27172
CAS:1233152-82-3
分子式:C178H248N44O45S7
分子量:3948.61
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Kv2.1 and Kv2.2 channel blocker (IC50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the Kv2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.


Li et al (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of Ins and somatostatin release from pancreatic islets. J.Pharmacol.Exp.Ther. 344 407 PMID:23161216 |Herrington (2007) Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon 49 231 PMID:17101164