A muscarinic acetylcholine receptor antagonist
货号:ajcx24424
CAS:52-88-0
分子式:C18H26NO3•NO3
分子量：366.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC₅₀=<0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .^1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED₅₀value of 5.5 µg/kg.²Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.³

1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2.Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3.Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)