A fluorescent probe for in vivo tumor cell imaging
货号:ajcx23960
CAS:207399-07-3
分子式:C36H44ClN2•I
分子量：667.1
溶解度:Chloroform: 10 mg/ml,DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IR 780 is a heptamethine cyanine fluorescent probe forin vivoimaging of tumor cells.¹It displays excitation/emission maxima of 780/799 nm, respectively.²IR 780 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein , and targeted to the mitochondria.¹It has an additive effect on the increase in reactive oxygen species (ROS) production induced by sonodynamic therapy (SDT) in 4T1 breast cancer cells when used at a concentration of 16 &#181M.³IR 780 (0.2 mg/kg, i.v.) preferentially accumulates in tumor tissue in MCF-7, HeLa, and MG-63 mouse xenograft models and in a syngeneic mouse model of chemically induced lung tumors, and its fluorescence is detectable for up to 20 days. It also has an additive effect on the SDT-induced reduction in tumor growth in an 4T1 murine mammary carcinoma model. IR 780 has been incorporated into heparin-folic acid-IR 780 nanoparticles for use in photothermal therapy.⁴

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