Paclitaxel-d5 是氘标记的紫杉醇。紫杉醇是一种天然存在的抗肿瘤剂，可稳定微管蛋白聚合。
货号:ajcx23198
CAS:1129540-33-5
分子式:C47H46D5NO14
分子量：859
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Paclitaxel-d₅contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC₅₀values ranging from 2.5-7.5 nM.¹It disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC₅₀s = 6.7-18.5 nM) at both prophase and G₁.²It also initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.³

1.Liebmann, J.E., Cook, J.A., Lipschultz, C., et al.Cytotoxic studies of paclitaxel (Taxol) in human tumour cell linesBr. J. Cancer68(6)1104-1109(1993) 2.Woods, C.M., Zhu, J., McQueney, P.A., et al.Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathwayMol. Med.1(5)506-526(1995) 3.Wang, T.h., Wang, H.S., and Soong, Y.K.Paclitaxel-induced cell death: Where the cell cycle and apoptosis come togetherCancer88(11)2619-2628(2000)