An internal standard for the quantification of nabumetone
货号:ajcx23040
CAS:1216770-08-9
分子式:C15H13D3O2
分子量：231.3
溶解度:Chloroform: slightly soluble,Ethyl Acetate: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nabumetone-d₃is intended for use as an internal standard for the quantification of nabumetone by GC- or LC-MS. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid .¹Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED₅₀= 11 mg/kg).²It reduces phenyl-p-quinone-induced writhing in mice (ED₅₀= 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.

1.Cryer, B., and Feldman, M.Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugsAm. J. Med.104(5)413-421(1998) 2.Boyle, E.A., Freeman, P.C., Mangan, F.R., et al.Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agentJ. Pharm. Pharmacol.34(9)562-569(1982)