| 规格: | 98% |
| 分子量: | 289.6 |
| 包装 | 价格(元) |
| 5g | 电议 |
| 10g | 电议 |
| 50g | 电议 |
Background:
L-Ascorbic acid is essential for the synthesis of collagen, with deficiency resulting in scurvy.1Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis.1L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture.2,3It may be included in media to enhance the survival of human embryonic stem cells or increase the growth and replicative lifespan of human corneal endothelial cells.4,5AA2P is also used to drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.6,7,8
1.Gropper, S.S., Smith, J.L., and Groff, J.L.The water-soluble vitaminsAdvanced Nutrition and Human Metabolism4259-275(2005) 2.Kurata, S., and Hata, R.Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivativeThe Journal of Biological Chemisty266(15)9997-10003(1991) 3.Yoshikawa, K., Takahashi, S., Imamura, Y., et al.Secretion of non-helical collagenous polypeptides of α1(IV) and α2(IV) chains upon depletion of ascorbate by cultured human cellsJournal of Biochemistry129(6)929-936(2001) 4.Furue, M.K., Na, J., Jackson, J.P., et al.Heparin promotes the growth of human embryonic stem cells in a defined serum-free mediumProceedings of the National Academy of Sciences of the United States of America105(36)13409-13414(2008) 5.Kimoto, M., Shima, N., Yamaguchi, M., et al.Role of hepatocyte growth factor in promoting the growth of human corneal endothelial cells stimulated by L-ascorbic acid 2-phosphateInvest.Ophthalmol.Vis.Sci.53(12)7583-7589(2012) 6.KyllÖnen, L., Maimi, S., MannerstrÖm, B., et al.Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitroStem Cell Res.Ther.4(1)1-15(2013) 7.Fang, X., Murakami, H., Demura, S., et al.A novel method to apply osteogenic potential of adipose derived stem cells in orthopaedic surgeryPLoS One9(2)1-6(2014) 8.Mariner, P.D., Johannesen, E., and Anseth, K.S.Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffoldsJ.Tissue Eng.Regen.Med.6(4)314-324(2012)
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