白消安-D8 是一种氘标记的白消安。白消安是一种烷基磺酸盐，可作为烷基化抗肿瘤剂。白消安在 DNA 上形成链内和链间交联。在哺乳动物中，白消安会导致造血祖细胞的产生显着和长期减少，而不会显着影响淋巴细胞水平或体液抗体反应。
货号:ajcx21868
CAS:116653-28-2
分子式:C6H6D8O6S2
分子量：254.3
溶解度:DMF: 16.7 mg/ml,DMSO: 16.7 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Busulfan-d₈is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.¹It forms both intra- and interstrand crosslinks on DNA.^2,3In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.⁴

1.Appelbaum, F.R.Optimizing the conditioning regimen for acute myeloid leukemiaBest Pract.Res.Clin.Haematol.22(4)543-550(2009) 2.Iwamoto, T., Hiraku, Y., Oikawa, S., et al.DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effectCancer Science95454-458(2004) 3.Ponti, M., Souhami, R.L., Fox, B.W., et al.DNA interstrand crosslinking and sequence selectivity of dimethanesulphonatesBritish Journal of Cancer63(5)743-747(1991) 4.Copelan, E.A., and Deeg, H.J.Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiationBlood80(7)1648-1658(1992)