An allomonohydroxy bile acid
货号:ajcx21644
CAS:2276-93-9
分子式:C24H40O3
分子量：376.6
溶解度:DMF: 1mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 &#181M in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]

参考文献:
[1].Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008)
[2].Vonk, R.J., Tuchweber, B., Massé, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)