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Nonapeptide-1(acetate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nonapeptide-1(acetate)图片
规格:98%
分子量:1206.5
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
C61H87N15O9S.XC2H4O2
货号:ajcx19552
CAS:N/A
分子式:C61H87N15O9S.XC2H4O2
分子量:1206.5
溶解度:PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nonapeptide-1 is an antagonist of melanocortin receptor 1 (MC1R; Ki = 40 nM in COS-1 cells expressing human receptors).1 It is selective for MC1R over MC3R, MC4R, and MC5R (Kis = 470, 1,340, and 2,400 nM, respectively). Nonapeptide-1 inhibits cAMP accumulation and melanosome dispersion induced by α-melanocyte-stimulating hormone (α-MSH) in melanocytes with IC50 values of 2.5 and 11 nM, respectively.2

参考文献
1. Schi•th, H.B., Muceniece, R., and Wikberg, J.E.S. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997).
2. Jayawickreme, C.K., Quillan, J.M., Graminski, G.F., et al. Discovery and structure-function analysis of α-melanocyte-stimulating hormone antagonists. J. Biol. Chem. 269(47), 29846-29854 (1994).