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Glaucocalyxin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glaucocalyxin A图片
规格:98%
分子量:332.43
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Glaucocalyxin A,一种来自日本黑纹病菌 (Rabdosia japonica var.) 的对映型月桂基二萜,通过调节 PI3K/Akt 信号通路抑制 GLI1 的核易位,从而诱导骨肉瘤凋亡。Glaucocalyxin A 具有抗肿瘤作用。
货号:ajcx15052
CAS:79498-31-0
分子式:C20H28O4
分子量:332.43
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].


[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.