WAY-213613 hydrochloride 是一个有效，选择性的，非底物再摄取 GLT-1/EAAT2 抑制剂，对 EAAT2 的 IC50 为 85 nM。WAY-213613 hydrochloride 对 EAAT1 和 EAAT3 的选择性是 59 倍和 44 倍 (IC50 分别为 5 和 3.8 μM)。WAY-213613 hydrochloride 对离子型和代谢型谷氨酸受体无活性。它是阐明 EAAT2 功能的潜在工具。
货号:ajcx14912
CAS:N/A
分子式:C16H14BrClF2N2O4
分子量：451.65
溶解度:DMSO: 50 mg/mL (110.71 mM; warming and heat to 80°C); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8 μM, respectively). WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function[1][2].

[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. [2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.