XY028-133 (example 14) 是基于PROTAC 的 CDK4/6 的降解剂。
货号:ajcx34244
CAS:2229974-73-4
分子式:C53H67N11O7S
分子量：1002.23
溶解度:DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1].

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

[1]. JIN, Jian， et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.