N-Bromoacetyl-β-alanine 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成PROTAC分子。N-Bromoacetyl-β-alanine 也是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
货号:ajcx32998
CAS:89520-11-6
分子式:C5H8BrNO3
分子量：210.03
溶解度:DMSO : 62.5 mg/mL (297.58 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.