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Thalidomide-Piperazine-PEG2-COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thalidomide-Piperazine-PEG2-COOH图片
包装:25mg
规格:98%
市场价:3969元
分子量:502.52

产品介绍
Thalidomide-Piperazine-PEG2-COOH 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。
货号:ajcx32934
CAS:N/A
分子式:C24H30N4O8
分子量:502.52
溶解度:DMSO : 250 mg/mL (497.49 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].


[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-992.