3α-Hydroxy pravastatin sodium 是 Pravastatin 的主要代谢产物。Pravastatin 是一种具有竞争性的 HMG-CoA 还原酶抑制剂。
货号:ajcx32928
CAS:81093-43-8
分子式:C23H35NaO7
分子量：446.51
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor[1][2].

[1]. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548‐554.
[2]. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559‐564.