mTORinhibitor-7是一种有口服活性的，可渗透大脑的mTOR抑制剂，其IC50为5nM。详细信息请参考专利文献WO2017198346A1中的化合物44。mTORinhibitor-7可用于神经疾病的研究。
货号:ajcx31134
CAS:1927857-98-4
分子式:C20H27F2N7O2
分子量：435.47
溶解度:DMSO: 100 mg/mL (229.64 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

mTOR inhibitor-7 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. mTOR inhibitor-7 can be used for the research of neurological disorder[1].

mTOR inhibitor-7 (0.04-5 μμ; 1 hour) has IC50s of 197 nM and 87 nM for pPKB S473 and pS6 S235/S236, respectively, in-cell western blot. S6 kinase (S6K), S6 ribosomal protein (S6rP) and 4E-binding protein (4E-BP) are prominent downstream effectors of mTOR[1]. Western Blot Analysis[1] Cell Line: A2058 cells

[1]. Denise RAGEOT, et al. Treatment of neurological disorders. WO2017198346A1.