(2S)-6-Prenylnaringenin是前脑中最有效的化合物。(2S)-6-Prenylnaringenin在α+β结合位点上起GABAA正变构调节剂的作用。
货号:ajcx29016
CAS:68236-13-5
分子式:C20H20O5
分子量：340.37
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin acts as a GABAA positive allosteric modulator at α+β- binding interface[1].

(2S)-6-Prenylnaringenin (6-Prenylnaringenin) displays a modulatory activity at low micromolar concentrations. (2S)-6-Prenylnaringenin potentiates GABA-induced displacement of [3H]EBOB binding in a concentration-dependent manner where the IC50 value for this potentiation in native GABAA receptors is 3.7 μM, respectively[1].

[1]. Ali Y Benkherouf, et al. Hops Compounds Modulatory Effects and 6-prenylnaringenin Dual Mode of Action on GABA AReceptors. Eur J Pharmacol. 2020 Apr 15;873:172962.