Mps1-IN-1 dihydrochloride 是一种有效的 ATP 竞争性 Mps1 激酶抑制剂，IC50 为 367 nM。 Mps1-IN-1 dihydrochloride 抑制 Mps1 有丝分裂激酶活性并消除纺锤体装配检查点 (SAC) 功能。 Mps1-IN-1 dihydrochloride 会降低癌细胞和"正常"细胞的活力。
货号:ajcx26942
CAS:1883548-93-3
分子式:C28H33N5O4S.2HCl
分子量：608.58
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID:20383151 |Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID:21802008 |Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID:20624898