A cardiac glycoside with cytotoxic and cardiac modulatory activities
货号:ajcx26342
CAS:25633-33-4
分子式:C32H48O9
分子量：576.7
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cerberin is a cardiac glycoside that has been found inC. odollamand has cytotoxic and cardiac modulatory activities.^1,2It is cytotoxic to KB and NCI H187 cancer cells (IC₅₀s = 1.92 and 1.24 µg/ml).¹Cerberin inhibits Na⁺/K⁺-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.²

1.Laphookhieo, S., Cheenpracha, S., Karalai, C., et al.Cytotoxic cardenolide glycoside from the seeds of Cerbera odollamPhytochemistry65(4)507-510(2004) 2.Menezes, R.G., Usman, M.S., Hussain, S.A., et al.Cerbera odollam toxicity: A reviewJ. Forensic Leg. Med.58113-116(2018)