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Dichlorvos-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dichlorvos-d6图片
规格:98%
分子量:227
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of dichlorvos
货号:ajcx25548
CAS:203645-53-8
分子式:C4HCl2D6O4P
分子量:227
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dichlorvos-d6is intended for use as an internal standard for the quantification of dichlorvos by GC- or LC-MS. Dichlorvos is an organophosphate insecticide and inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 269 and 44 nM, respectively).1It also binds to the M2muscarinic receptor in rat heart homogenates.2Dichlorvos is lethal to 4-week old German cockroach (B. germanica) nymphs (LD50= 0.108 μg per insect) and silkworms (B. mori) in third instar (LC50= 6.63 mg/L) after 24 hours.3,4It is lethal to zebrafish (D. rerio) embryos (LC50= 39.75 mg/L after 24 hours) and decreases swimming activity of larvae 6 days after fertilization when administered at a concentration of 25 mg/L in tank water.5Dichlorvos (150 ppm for 80 weeks) also increases the incidence of benign and malignant neoplasms in male rats from 47 to 88% as compared to controls.6


1.Petroianu, G.A., Schmitt, A., Arafat, K., et al.Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): In vitro effect of tiaprideInt. J. Toxicol.24(2)79-86(2005) 2.Silveira, C.L., Eldefrawi, A.T., and Eldefrawi, M.E.Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterasesToxicol. Appl. Pharmacol.103(3)474-481(1990) 3.Qian, K., Wei, X., Zeng, X., et al.Stage-dependent tolerance of the German cockroach, Blattella germanica for dichlorvos and propoxuJ. Insect Sci.10(1)201(2010) 4.Zhang, Z.-Y., Wang, D.-L., Chi, Z.-J., et al.Acute toxicity of organophosphorus and pyrethroid insecticides to Bombyx moriJ. Econ. Entomol.101(2)360-364(2008) 5.Si?man, T.Dichlorvos-induced developmental toxicity in zebrafishToxicol. Ind. Health26(9)567-573(2010) 6.Reuber, M.D.Carcinogenicity of dichlorvosClin. Toxicol.18(1)47-84(1981)