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Maduramicin(ammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maduramicin(ammonium salt)图片
规格:98%
分子量:934.2
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
A polyether ionophore antibiotic
货号:ajcx25384
CAS:84878-61-5
分子式:C47H79O17·NH4
分子量:934.2
溶解度:DMF: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Maduramicin is a polyether ionophore antibiotic that has been found inNocardia.1It selectively binds to potassium, rubidium, sodium, lithium, and cesium ions over divalent cations. Maduramicin is active against Gram-positive bacteria (MICs = 0.9-125 µg/ml) but not Gram-negative bacteria (MICs = >1,000 µg/ml) or fungi (MICs = 250->1,000 µg/ml). It reduces the viability of asexual and gametocyteP. falciparumparasites (EC50s = 1.3 and 14.8 nM, respectively) and reducesP. bergheitransmission in a mouse model of malaria when administered at doses of 4 and 8 mg/kg.2Maduramicin (5-10 ppm in the diet) reduces the severity of lesions and completely protects chicks against mortality in a model of coccidiosis induced byE. tenella.1Formulations containing maduramicin have been used in the treatment of coccidiosis in chickens.


1.Liu, C.-M., Hermann, T.E., Downey, A., et al.Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing cultureJ. Antibiot. (Tokyo)36(4)343-350(1983) 2.Maron, M.I., Magle, C.T., Czeny, B., et al.Maduramicin rapidly eliminates malaria parasites and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050Antimicrob. Agents Chemother.60(3)1492-1499(2015)